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Affiliation Agency from Actual Medication and you can Rehabilitation, Taipei Tzu Chi Healthcare, Buddhist Tzu Chi Scientific Basis, The latest Taipei Area, Taiwan
Affiliations Section from Rheumatology, Allergic reaction, and you may Immunology, Company out-of Interior Medicine, Kaohsiung Chang Gung Memorial Medical, Kaohsiung, Taiwan, Chang Gung College University out-of Medicine, Kaohsiung, Taiwan
Associations Chang Gung University School of Medication, Kaohsiung, Taiwan, Department from Obstetrics and you can Gynecology, Kaohsiung Chang Gung Memorial Medical, Kaohsiung, Taiwan
Associations Division regarding Rheumatology, Allergic reaction, and you can Immunology, Agency from Internal Medication, Kaohsiung Chang Gung Art gallery Hospital, Kaohsiung, Taiwan, Chang Gung College or university School of Drug, Kaohsiung, Taiwan
- Fu-Mei Su,
- Dung-Huan Liu,
- Jia-Feng Chen,
- Shan-Fu Yu,
- Wen-Chan Chiu,
- Chung-Yuan Hsu,
Records
To cultivate a keen OSTAi equipment and you can examine which with the National Osteoporosis Base information within the 2013 (NOF 2013) for bones mineral density (BMD) research certainly one of Taiwan postmenopausal lady.
Strategies
Taiwan Osteoporosis Organization (TOA) conducted a nationwide BMD survey by the a coach installed which have good twin time X-ray absorptiometry (DXA) between 2008 and 2011. All of the members complete questionnaire, which included class and chance points of osteoporotic break when you look at the FRAX equipment. We made use of the database to research prospective exposure situations to possess osteoporosis and you will adopted the model of the Koh mais aussi al. to develop a danger list through numerous variable regression research and you will item prevention. We utilized the index viewpoints to set up an easy formula (namely OSTAi) to spot people who need BMD dimensions. Recipient doing work characteristic (ROC) contour and city underneath the contour (AUC) was utilized to compare the brand new awareness/specificity data on the model thereupon from advice by NOF 2013.
Performance
All in all, a dozen,175 Taiwan postmenopausal ladies signed up for so it survey. The fresh new index value was derived by age and the body lbs of the players according to adjusted probability of each risk grounds and you may the latest chosen cutoff well worth was set at the “-1”. You will find 6393 (52.5%) users whose index well worth was below “-1” and you can whoever danger of weakening of bones are 57.5% (). The new AUC to possess OSTAi and you may NOF 2013 was 0.739 (95% believe period (CI), 0.728–0.749, P dos ), previous crack, high risk therapy have fun with on the low bones bulk otherwise bone loss (elizabeth.grams., glucocorticoid inside the a daily amounts ? 5 mg prednisone or equivalent having ? 3 months), otherwise situation otherwise standing of this bones losses (e.g., rheumatoid arthritis). This new symptomatic results out-of NOF 2013 getting forecasting osteoporosis within learned society ended up being reviewed.
Statistical Analysis
I followed the statistical analysis by the Koh ainsi que al. with some amendment. The possibility risk situations getting osteoporosis included in the design advancement process contains the risk issues about FRAX device, where ethnic foundation wasn’t integrated.
